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Coordination between TGF-β cellular signaling and epigenetic regulation during epithelial to mesenchymal transition.

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第一作者： Congcong,Lu

第一单位： Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

作者： Congcong,Lu ^[1] ; Simone,Sidoli ^[1] ; Katarzyna,Kulej ^[2] ; Karen,Ross ^[3] ; Cathy H,Wu ^[3] ; Benjamin A,Garcia ^[4]

作者单位： Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. ^[1] Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.;Division of Cancer Pathobiology, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA. ^[2] Center for Bioinformatics and Computational Biology, Department of Computer and Information Sciences, University of Delaware, Newark, DE, 19711, USA. ^[3] Epigenetics Institute, Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. bgarci@pennmedicine.upenn.edu. ^[4]

关键词 Combinatorial inhibition targeting signaling pathway and epigenetic regulator Comprehensive profiling of histone modifications Epithelial to mesenchymal transition Erk signaling Histone H3 lysine 27 trimethylation Time-resolved quantitative (phospho)proteomics