Novel genetically-modified chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine safely boosts humoral and cellular immunity in healthy older adults.

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作者： Christopher A,Green ^[1] ; Charles J,Sande ^[2] ; Elisa,Scarselli ^[3] ; Stefania,Capone ^[4] ; Alessandra,Vitelli ^[4] ; Alfredo,Nicosia ^[5] ; Laura,Silva-Reyes ^[2] ; Amber J,Thompson ^[2] ; Catherine M,de Lara ^[6] ; Kathryn S,Taylor ^[7] ; Kathryn,Haworth ^[2] ; Claire L,Hutchings ^[6] ; Tamsin,Cargill ^[6] ; Brian,Angus ^[2] ; Paul,Klenerman ^[6] ; Andrew J,Pollard ^[2]

作者单位： Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom. Electronic address: christopher.green@paediatrics.ox.uk. ^[1] Oxford Vaccine Group, Department of Paediatrics and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom. ^[2] Nouscom Srl, via di Castel Romano 100, 00128 Roma, Italy. ^[3] ReiThera Srl, Via di Castel Romano 100, 00128 Roma, Italy. ^[4] Keires AG, Baumleingasse 18, CH 4051 Basel, Switzerland; CEINGE, Via Gaetano Salvatore 486, 80145 Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy. ^[5] Experimental Medicine Division, Nuffield Department of Medicine, University of Oxford, Peter Medawar building, Oxford OX1 3SY, United Kingdom. ^[6] Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, United Kingdom. ^[7]

关键词 Elderly Older adults Respiratory syncytial virus Vaccine Viral vectors