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Toward a treatment of diabesity: Rational design, synthesis and biological evaluation of benzene-sulfonamide derivatives as a new class of PTP-1B inhibitors.

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第一作者： Nagat,Ghareb

第一单位： Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt; Chemistry Department, College of Sciences, Prince Sattam bin Abdul-Aziz University, Saudi Arabia.

作者： Nagat,Ghareb ^[1] ; Norhan M,El-Sayed ^[2] ; Reda,Abdelhameed ^[3] ; Koji,Yamada ^[4] ; Mohamed Saleh,Elgawish ^[5]

作者单位： Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt; Chemistry Department, College of Sciences, Prince Sattam bin Abdul-Aziz University, Saudi Arabia. ^[1] Pharmacology and Toxicology Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. ^[2] Graduate school of biomedical sciences, Nagasaki University to Pharmacognosy Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. ^[3] Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. ^[4] Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. Electronic address: mohamed_elgawish@pharm.suez.edu.eg. ^[5]

关键词 Benzene-sulfonamide In silico ADME prediction Molecular modeling, DFT calculation PTP1B inhibitors Synthesis and biological evaluation