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Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation.

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第一作者： Sonja M,Sachse

第一单位： VIB Center for Brain & Disease Research, Leuven, Belgium.;Department of Neurosciences, KU Leuven, Leuven, Belgium.

作者： Sonja M,Sachse ^[1] ; Sam,Lievens ^[2] ; Luís F,Ribeiro ^[1] ; Dan,Dascenco ^[1] ; Delphine,Masschaele ^[2] ; Katrien,Horré ^[1] ; Anke,Misbaer ^[1] ; Nele,Vanderroost ^[2] ; Anne Sophie,De Smet ^[2] ; Evgenia,Salta ^[1] ; Maria-Luise,Erfurth ^[3] ; Yoshiaki,Kise ^[3] ; Siegfried,Nebel ^[1] ; Wouter,Van Delm ^[4] ; Stéphane,Plaisance ^[4] ; Jan,Tavernier ^[2] ; Bart,De Strooper ^[5] ; Joris,De Wit ^[1] ; Dietmar,Schmucker ^[6]

作者单位： VIB Center for Brain & Disease Research, Leuven, Belgium.;Department of Neurosciences, KU Leuven, Leuven, Belgium. ^[1] VIB Center for Medical Biotechnology, Ghent, Belgium.;Department of Biomolecular Medicine, Ghent University, Ghent, Belgium. ^[2] VIB Center for Brain & Disease Research, Leuven, Belgium. ^[3] VIB Nucleomics Core, Leuven, Belgium. ^[4] VIB Center for Brain & Disease Research, Leuven, Belgium.;Department of Neurosciences, KU Leuven, Leuven, Belgium.;Dementia Research Institute, University College London, London, UK. ^[5] VIB Center for Brain & Disease Research, Leuven, Belgium dietmar.schmucker@kuleuven.vib.be.;Department of Neurosciences, KU Leuven, Leuven, Belgium. ^[6]

关键词 DSCAM nuclear translocation proteolytic cleavage synapse formation transcriptional regulation