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Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of <i>Cryptosporidium</i> Infection.

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第一作者： Frederick S,Buckner

第一单位： Department of Medicine, University of Washington, Seattle, Washington, USA fbuckner@uw.edu erkang@uw.edu.

作者： Frederick S,Buckner ^[1] ; Ranae M,Ranade ^[2] ; J Robert,Gillespie ^[2] ; Sayaka,Shibata ^[3] ; Matthew A,Hulverson ^[2] ; Zhongsheng,Zhang ^[3] ; Wenlin,Huang ^[3] ; Ryan,Choi ^[2] ; Christophe L M J,Verlinde ^[3] ; Wim G J,Hol ^[3] ; Atsuko,Ochida ^[4] ; Yuichiro,Akao ^[4] ; Robert K M,Choy ^[5] ; Wesley C,Van Voorhis ^[2] ; Sam L M,Arnold ^[2] ; Rajiv S,Jumani ^[6] ; Christopher D,Huston ^[6] ; Erkang,Fan ^[7]

作者单位： Department of Medicine, University of Washington, Seattle, Washington, USA fbuckner@uw.edu erkang@uw.edu. ^[1] Department of Medicine, University of Washington, Seattle, Washington, USA. ^[2] Department of Biochemistry, University of Washington, Seattle, Washington, USA. ^[3] Takeda Pharmaceuticals, Osaka, Japan. ^[4] Drug Development Program, PATH, San Francisco, California, USA. ^[5] Department of Medicine, University of Vermont, Burlington, Vermont, USA. ^[6] Department of Biochemistry, University of Washington, Seattle, Washington, USA fbuckner@uw.edu erkang@uw.edu. ^[7]

关键词 Cryptosporidium diarrhea drug discovery pharmacokinetics tRNA synthetase

医学主题词动物(Animals);抗原虫药(Antiprotozoal Agents);隐孢子虫病(Cryptosporidiosis);小隐孢子虫(Cryptosporidium parvum);环氧化酶1(Cyclooxygenase 1);疾病模型, 动物(Disease Models, Animal);药物发现(Drug Discovery);女(雌)性(Female);Hep G2细胞(Hep G2 Cells);人类(Humans);咪唑类(Imidazoles);甲硫氨酸tRNA连接酶(Methionine-tRNA Ligase);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);吡啶类(Pyridines)

DOI 10.1128/AAC.02061-18

PMID 30745384

发布时间 2024-04-12

基金项目

P20 RR021905/RR/NCRR NIH HHS/United States R21 AI130807/AI/NIAID NIH HHS/United States HHSN271201700059C/DA/NIDA NIH HHS/United States R01 AI097177/AI/NIAID NIH HHS/United States P20 GM125498/GM/NIGMS NIH HHS/United States HHSN272201700059C/AI/NIAID NIH HHS/United States P30 GM118228/GM/NIGMS NIH HHS/United States

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