How complex should an in vitro model be? Evaluation of complex 3D alveolar model with transcriptomic data and computational biological network models.

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作者： Diego,Marescotti ^[1] ; Tommaso,Serchi ^[2] ; Karsta,Luettich ^[1] ; Yang,Xiang ^[1] ; Elisa,Moschini ^[2] ; Marja,Talikka ^[1] ; Florian,Martin ^[1] ; Karine,Baumer ^[1] ; Remi,Dulize ^[1] ; Dariusz,Peric ^[1] ; David,Bornand ^[1] ; Emmanuel,Guedj ^[1] ; Alain,Sewer ^[1] ; Sebastian,Cambier ^[2] ; Servane,Contal ^[2] ; Aline,Chary ^[2] ; Arno C,Gutleb ^[2] ; Stefan,Frentzel ^[1] ; Nikoloai V,Ivanov ^[1] ; Manuel C,Peitsch ^[1] ; Julia,Hoeng ^[1]

作者单位： PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland. ^[1] Luxembourg Institute of Science and Technology (LIST), Esch-sur-Alzette, Luxembourg. ^[2]

关键词 alveolar model co-culture air-liquid interface physiological relevance

主题词共同培养技术(Coculture Techniques);计算生物学(Computational Biology);基因表达(Gene Expression);人类(Humans);肺(Lung);巨噬细胞(Macrophages);模型, 生物学(Models, Biological)

DOI 10.14573/altex.1811221

PMID 30753736

发布时间 2020-01-13

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