Entry of therapeutics into the brain: Influence of exposed polarity calculated in silico and measured in vitro by supercritical fluid chromatography.

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作者： Giacomo,Russo ^[1] ; Francesco,Barbato ^[2] ; Lucia,Grumetto ^[2] ; Laurence,Philippe ^[3] ; Frederic,Lynen ^[4] ; Gilles H,Goetz ^[5]

作者单位： Pharm-Analysis & Bio-Pharm Laboratory, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, I-80131 Naples, Italy; Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, B-9000 Ghent, Belgium. ^[1] Pharm-Analysis & Bio-Pharm Laboratory, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano, 49, I-80131 Naples, Italy. ^[2] Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, United States. ^[3] Separation Science Group, Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281, S4-bis, B-9000 Ghent, Belgium. ^[4] Worldwide Medicinal Chemistry, Pfizer Global Research & Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, United States. Electronic address: gilles.h.goetz@pfizer.com. ^[5]

关键词 Accessible surface area Blood-brain barrier EPSA Immobilized artificial membranes Supercritical fluid chromatography