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Challenge model of TNF<sub>α</sub> turnover at varying LPS and drug provocations.

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第一作者： Felix,Held

第一单位： Fraunhofer-Chalmers Centre, Chalmers Science Park, Gothenburg, Sweden. felix.held@chalmers.se.;Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden. felix.held@chalmers.se.

作者： Felix,Held ^[1] ; Edmund,Hoppe ^[2] ; Marija,Cvijovic ^[3] ; Mats,Jirstrand ^[4] ; Johan,Gabrielsson ^[5]

作者单位： Fraunhofer-Chalmers Centre, Chalmers Science Park, Gothenburg, Sweden. felix.held@chalmers.se.;Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden. felix.held@chalmers.se. ^[1] Grünenthal GmbH, Aachen, Germany. ^[2] Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden. ^[3] Fraunhofer-Chalmers Centre, Chalmers Science Park, Gothenburg, Sweden. ^[4] Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7028, 75007, Uppsala, Sweden. ^[5]

关键词 Challenge tests Experimental design Kinetic-dynamic modelling Non-linear mixed effects modelling Target biology

医学主题词动物(Animals);脂多糖类(Lipopolysaccharides);男(雄)性(Male);模型, 生物学(Models, Biological);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)

DOI 10.1007/s10928-019-09622-x

PMID 30778719

发布时间 2020-05-08

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准确一般字义偏差语意偏离译文作用小提交