Mutagenesis of α-Conotoxins for Enhancing Activity and Selectivity for Nicotinic Acetylcholine Receptors.

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第一作者： Matthew W,Turner

第一单位： Biomolecular Sciences Graduate Programs, Boise State University; Boise, ID 83725, USA. matthewturner1@u.boisestate.edu.

作者： Matthew W,Turner ^[1] ; Leanna A,Marquart ^[2] ; Paul D,Phillips ^[3] ; Owen M,McDougal ^[4]

作者单位： Biomolecular Sciences Graduate Programs, Boise State University; Boise, ID 83725, USA. matthewturner1@u.boisestate.edu. ^[1] Department of Chemistry and Biochemistry, Boise State University; Boise, ID 83725, USA. leannabrown@boisestate.edu. ^[2] Department of Chemistry and Biochemistry, Boise State University; Boise, ID 83725, USA. paul.dan.phillips@gmail.com. ^[3] Department of Chemistry and Biochemistry, Boise State University; Boise, ID 83725, USA. owenmcdougal@boisestate.edu. ^[4]

关键词 acetylcholine binding protein (AChBP)genetic algorithm managed peptide mutant screening (GAMPMS)molecular dynamics (MD)mutational analysis nicotinic acetylcholine receptors (nAChRs)positional scanning synthetic combinatorial libraries (PS-SCL)protein surface topography (PST)solid phase peptide synthesis (SPPS)α-conotoxins (α-CTxs)