Cholesterol content in cell membrane maintains surface levels of ErbB2 and confers a therapeutic vulnerability in ErbB2-positive breast cancer.

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第一作者： Jinrui,Zhang

第一单位： Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.

作者： Jinrui,Zhang ^[1] ; Qiong,Li ^[2] ; Yueguang,Wu ^[1] ; Duchuang,Wang ^[1] ; Lu,Xu ^[3] ; Yang,Zhang ^[1] ; Shanshan,Wang ^[1] ; Taishu,Wang ^[1] ; Fang,Liu ^[1] ; Mohamed Y,Zaky ^[4] ; Shuai,Hou ^[1] ; Shuyan,Liu ^[1] ; Kun,Zou ^[5] ; Haixin,Lei ^[1] ; Lijuan,Zou ^[3] ; Yingqiu,Zhang ^[6] ; Han,Liu ^[7]

作者单位： Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China. ^[1] Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.;The Second Affiliated Hospital, Dalian Medical University, Dalian, China. ^[2] The Second Affiliated Hospital, Dalian Medical University, Dalian, China. ^[3] Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China.;Molecular Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, Beni Suef, Egypt. ^[4] Department of Radiotherapy Oncology, the First Affiliated Hospital of Dalian Medical University, Dalian, China. ^[5] Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China. zhangyingqiu.no.1@163.com. ^[6] Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China. liuhan@dlmedu.edu.cn.;Cancer Biotherapy & Translational Medicine Center of Liaoning Province, Dalian Medical University, Dalian, China. liuhan@dlmedu.edu.cn. ^[7]

关键词 Breast cancer Cholesterol ErbB2 Lovastatin Membrane fluidity Membrane rigidity