首页> PloS one> Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function.

Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function.

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第一作者： Jean J,Kim

第一单位： Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America.;Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America.

作者： Jean J,Kim ^[1] ; Jeffrey N,Savas ^[2] ; Meghan T,Miller ^[3] ; Xindao,Hu ^[1] ; Cassiano,Carromeu ^[4] ; Mathieu,Lavallée-Adam ^[2] ; Beatriz C G,Freitas ^[4] ; Alysson R,Muotri ^[4] ; John R,Yates ^[2] ; Anirvan,Ghosh ^[5]

作者单位： Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America.;Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America. ^[1] Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, United States of America. ^[2] Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland. ^[3] Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America. ^[4] Section of Neurobiology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America.;Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland. ^[5]

医学主题词细胞分化(Cell Differentiation);细胞系(Cell Line);女(雌)性(Female);基因表达调控, 发育期(Gene Expression Regulation, Developmental);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);男(雄)性(Male);甲基-CpG-结合蛋白质2(Methyl-CpG-Binding Protein 2);神经干细胞(Neural Stem Cells);神经胶质(Neuroglia);蛋白质组学(Proteomics);RNA结合蛋白质类(RNA-Binding Proteins)

DOI 10.1371/journal.pone.0212553

PMID 30789962

发布时间 2024-11-15

基金项目

P41 GM103533/GM/NIGMS NIH HHS/United States R01 MH067880/MH/NIMH NIH HHS/United States DP2 OD006495/OD/NIH HHS/United States R01 MH100175/MH/NIMH NIH HHS/United States K99 DC013805/DC/NIDCD NIH HHS/United States

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