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首页> European journal of pharmacology> Stearoyl lysophosphatidylcholine inhibits LPS-induced extracellular release of HMGB1 through the G2A/calcium/CaMKKβ/AMPK pathway.

Stearoyl lysophosphatidylcholine inhibits LPS-induced extracellular release of HMGB1 through the G2A/calcium/CaMKKβ/AMPK pathway.

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作者： Hui,Quan ^[1] ; Hong-Beom,Bae ^[2] ; Young-Hoe,Hur ^[3] ; Kyung-Hwa,Lee ^[4] ; Chang-Hun,Lee ^[1] ; Eun-A,Jang ^[5] ; Seongtae,Jeong ^[5]

作者单位： Department of Anesthesiology and Pain Medicine, Chonnam National University Medical School, Gwangju, South Korea. ^[1] Department of Anesthesiology and Pain Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, South Korea. Electronic address: nextphil2@jnu.ac.kr. ^[2] Division of Hepatico-Biliary-Pancreatic Surgery, Department of Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea. ^[3] Department of Pathology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, South Korea. ^[4] Department of Anesthesiology and Pain Medicine, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Gwangju, South Korea. ^[5]

关键词 CaMKKβ HMGB1 LPS Macrophage Stearoyl lysophosphatidylcholine

主题词 AMP活化蛋白激酶类(AMP-Activated Protein Kinases);动物(Animals);钙(Calcium);钙-钙调素依赖性蛋白激酶激酶(Calcium-Calmodulin-Dependent Protein Kinase Kinase);细胞外间隙(Extracellular Space);HMGB1蛋白质(HMGB1 Protein);脂多糖类(Lipopolysaccharides);溶血磷脂酰胆碱类(Lysophosphatidylcholines);巨噬细胞(Macrophages);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);受体, CCR10(Receptors, CCR10);脓毒症(Sepsis);信号传导(Signal Transduction)

DOI 10.1016/j.ejphar.2019.02.038

PMID 30797785

发布时间 2019-09-03

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European journal of pharmacology

125-133页

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European journal of pharmacology

125-133页

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