Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca<sup>2+</sup> Leakage from the Endoplasmic Reticulum.

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作者： Igor,Gamayun ^[1] ; Sarah,O'Keefe ^[2] ; Tillman,Pick ^[3] ; Marie-Christine,Klein ^[4] ; Duy,Nguyen ^[5] ; Craig,McKibbin ^[2] ; Michela,Piacenti ^[6] ; Helen M,Williams ^[6] ; Sabine L,Flitsch ^[6] ; Roger C,Whitehead ^[6] ; Eileithyia,Swanton ^[2] ; Volkhard,Helms ^[5] ; Stephen,High ^[2] ; Richard,Zimmermann ^[4] ; Adolfo,Cavalié ^[7]

作者单位： Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421 Homburg, Germany. Electronic address: igor.gamayun@uks.eu. ^[1] School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK. ^[2] Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421 Homburg, Germany. ^[3] Medical Biochemistry and Molecular Biology, Saarland University, 66421 Homburg, Germany. ^[4] Center for Bioinformatics, Saarland University, 66123 Saarbrücken, Germany. ^[5] School of Chemistry, University of Manchester, Manchester M13 9PL, UK. ^[6] Experimental and Clinical Pharmacology and Toxicology, Saarland University, 66421 Homburg, Germany. Electronic address: adolfo.cavalie@uks.eu. ^[7]

关键词 Protein translocation and degradation Sec61 complexes of the endoplasmic reticulum calcium homeostasis calcium-dependent cytotoxicity eeyarestatin endoplasmic reticulum endoplasmic reticulum calcium content endoplasmic reticulum calcium homeostasis endoplasmic reticulum calcium leakage translocon of endoplasmic reticulum

主题词钙(Calcium);细胞系(Cell Line);内质网(Endoplasmic Reticulum);HEK293细胞(HEK293 Cells);人类(Humans);腙类(Hydrazones);羟基脲(Hydroxyurea);蛋白质转运(Protein Transport)

DOI 10.1016/j.chembiol.2019.01.010

PMID 30799222

发布时间 2020-03-09

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Cell chemical biology

2019年26卷4期

571-583.e6页

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Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca<sup>2+</sup> Leakage from the Endoplasmic Reticulum.

Cell chemical biology

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Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca<sup>2+</sup> Leakage from the Endoplasmic Reticulum.

Cell chemical biology

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Cell chemical biology

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