FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury.

导出 OA

翻译打印收藏纠错

第一作者： Bo,Kong

第一单位： School of Life Sciences, Guangzhou University, Guangzhou, China; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States.

作者： Bo,Kong ^[1] ; Min,Zhang ^[2] ; Mingxing,Huang ^[3] ; Dan,Rizzolo ^[4] ; Laura E,Armstrong ^[4] ; Justin D,Schumacher ^[4] ; Monica D,Chow ^[5] ; Yi-Horng,Lee ^[6] ; Grace L,Guo ^[7]

作者单位： School of Life Sciences, Guangzhou University, Guangzhou, China; Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States. ^[1] Children's Liver Disease Center, 302 Military Hospital, Beijing, China. ^[2] Department of Infectious Diseases, The Fifth Affiliated Hospital of Sun Yat-Sen University (SYSU), Zhuhai, Guangdong, China. ^[3] Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States. ^[4] Department of General Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, United States. ^[5] Division of Pediatric Surgery, Department of Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, United States. ^[6] Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States; Environmental and Occupational Health Sciences Institute (EOHSI), Rutgers, The State University of New Jersey, Piscataway, NJ, United States; VA New Jersey Health Care System, Veterans Administration Medical Center, East Orange, NJ, United States. Electronic address: guo@eohsi.rutgers.edu. ^[7]

关键词 Alcoholic liver disease Bile acid profile Ethanol toxicity Lipid metabolism Liver steatosis