The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus.

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作者： Matteo,Gentili ^[1] ; Xavier,Lahaye ^[1] ; Francesca,Nadalin ^[1] ; Guilherme P F,Nader ^[2] ; Emilia,Puig Lombardi ^[3] ; Solène,Herve ^[4] ; Nilushi S,De Silva ^[1] ; Derek C,Rookhuizen ^[1] ; Elina,Zueva ^[1] ; Christel,Goudot ^[1] ; Mathieu,Maurin ^[1] ; Aurore,Bochnakian ^[1] ; Sebastian,Amigorena ^[1] ; Matthieu,Piel ^[2] ; Daniele,Fachinetti ^[4] ; Arturo,Londoño-Vallejo ^[3] ; Nicolas,Manel ^[5]

作者单位： Immunity and Cancer Department, Institut Curie, PSL Research University, INSERM U932, 75005 Paris, France. ^[1] Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France; Institut Pierre-Gilles de Gennes, PSL Research University, 75005 Paris, France. ^[2] Institut Curie, PSL Research University, Sorbonne Universités, CNRS, UMR 3244 Telomere and Cancer Lab, 75005 Paris, France. ^[3] Institut Curie, PSL Research University, CNRS, UMR 144, 75005 Paris, France. ^[4] Immunity and Cancer Department, Institut Curie, PSL Research University, INSERM U932, 75005 Paris, France. Electronic address: nicolas.manel@curie.fr. ^[5]

关键词 IRF3 LINE STING cGAMP cGAS centromere dendritic cells interferon nuclear envelope satellite DNA