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Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures.

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第一作者： Nicolas,Merienne

第一单位： Department of Clinical Neurosciences, Laboratory of Neurotherapies and Neuromodulation (LNTM), Lausanne University Hospital, 1011 Lausanne, Switzerland; Neuroscience Research Center, LNTM, Lausanne University Hospital, 1011 Lausanne, Switzerland.

作者： Nicolas,Merienne ^[1] ; Cécile,Meunier ^[2] ; Anne,Schneider ^[3] ; Jonathan,Seguin ^[3] ; Satish S,Nair ^[4] ; Anne B,Rocher ^[5] ; Stéphanie,Le Gras ^[6] ; Céline,Keime ^[6] ; Richard,Faull ^[7] ; Luc,Pellerin ^[8] ; Jean-Yves,Chatton ^[9] ; Christian,Neri ^[4] ; Karine,Merienne ^[3] ; Nicole,Déglon ^[10]

作者单位： Department of Clinical Neurosciences, Laboratory of Neurotherapies and Neuromodulation (LNTM), Lausanne University Hospital, 1011 Lausanne, Switzerland; Neuroscience Research Center, LNTM, Lausanne University Hospital, 1011 Lausanne, Switzerland. ^[1] Department of Physiology, Laboratory of Neuroenergetics, University of Lausanne, 1005 Lausanne, Switzerland. ^[2] University of Strasbourg, CNRS, UMR 7364, Laboratory of Cognitive and Adaptive Neuroscience, 67000 Strasbourg, France. ^[3] Sorbonnes Université, Centre National de la Recherche Scientifique, Research Unit Biology of Adaptation and Aging, Team Compensation in Neurodegenerative Diseases and Aging, 75252 Paris, France. ^[4] Department of Fundamental Neurosciences, University of Lausanne, 1005 Lausanne, Switzerland. ^[5] University of Strasbourg, CNRS, INSERM, UMR 7104, Microarray and Sequencing Platform, Institute of Genetic and Molecular and Cellular Biology, 67404 Illkirch, France. ^[6] Centre for Brain Research, Faculty of Medical and Health Science, The University of Auckland, Auckland 1023, New Zealand. ^[7] Department of Physiology, Laboratory of Neuroenergetics, University of Lausanne, 1005 Lausanne, Switzerland; Centre de Résonance Magnétique des Systèmes Biologiques UMR 5536, CNRS-Université de Bordeaux, 146 rue Léo Saignat, Bordeaux, France. ^[8] Department of Fundamental Neurosciences, University of Lausanne, 1005 Lausanne, Switzerland; Cellular Imaging Facility, University of Lausanne, 1005 Lausanne, Switzerland. ^[9] Department of Clinical Neurosciences, Laboratory of Neurotherapies and Neuromodulation (LNTM), Lausanne University Hospital, 1011 Lausanne, Switzerland; Neuroscience Research Center, LNTM, Lausanne University Hospital, 1011 Lausanne, Switzerland. Electronic address: nicole.deglon@chuv.ch. ^[10]

关键词 HD patients HD transgenic mice Huntington’s disease cell-type-specific profiling epigenetics striatum transcriptomics