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首页> Pharmacological research> NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia.

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia.

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作者： Rebecca,Ward ^[1] ; Weiguo,Li ^[2] ; Yasir,Abdul ^[2] ; LaDonya,Jackson ^[3] ; Guangkuo,Dong ^[4] ; Sarah,Jamil ^[5] ; Jessica,Filosa ^[4] ; Susan C,Fagan ^[3] ; Adviye,Ergul ^[6]

作者单位： Departments of Neuroscience and Regenerative Medicine, Augusta University, Augusta, GA, United States. ^[1] Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States; Ralph H. Johnson Veterans Administration Medical Center, Charleston, SC, United States. ^[2] Center for Pharmacy and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, GA, United States. ^[3] Physiology, Augusta University, Augusta, GA, United States. ^[4] Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States. ^[5] Physiology, Augusta University, Augusta, GA, United States; Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, SC, United States. Electronic address: ergul@musc.edu. ^[6]

关键词 Diabetes Hippocampus NLRP3 inflammasome Neurovascular unit Stroke Vascular cognitive impairment and dementia (VCID)

主题词动物(Animals);细胞系(Cell Line);糖尿病, 实验性(Diabetes Mellitus, Experimental);呋喃类(Furans);海马(Hippocampus);茚类(Indenes);梗死, 大脑中动脉(Infarction, Middle Cerebral Artery);炎性体(Inflammasomes);男(雄)性(Male);小鼠(Mice);神经元(Neurons);神经保护药(Neuroprotective Agents);大鼠, Wistar(Rats, Wistar);磺胺类(Sulfonamides);砜类(Sulfones)

DOI 10.1016/j.phrs.2019.01.035

PMID 30818045

发布时间 2024-02-28

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