Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.-论文-万方医学网

第一作者： Caroline,Petitdemange

第一单位： Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, Georgia, USA.

作者： Caroline,Petitdemange ^[1] ; Sudhir Pai,Kasturi ^[1] ; Pamela A,Kozlowski ^[2] ; Rafiq,Nabi ^[2] ; Clare F,Quarnstrom ^[3] ; Pradeep Babu Jagadeesh,Reddy ^[1] ; Cynthia A,Derdeyn ^[4] ; Lori M,Spicer ^[4] ; Parin,Patel ^[1] ; Traci,Legere ^[1] ; Yevgeniy O,Kovalenkov ^[5] ; Celia C,Labranche ^[6] ; François,Villinger ^[7] ; Mark,Tomai ^[8] ; John,Vasilakos ^[8] ; Barton,Haynes ^[6] ; C Yong,Kang ^[9] ; James S,Gibbs ^[10] ; Jonathan W,Yewdell ^[10] ; Dan,Barouch ^[11] ; Jens,Wrammert ^[5] ; David,Montefiori ^[6] ; Eric,Hunter ^[1] ; Rama R,Amara ^[1] ; David,Masopust ^[3] ; Bali,Pulendran ^[12]

作者单位： Emory Vaccine Center, Yerkes National Primate Research Center at Emory University, Atlanta, Georgia, USA. ^[1] Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. ^[2] Department of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, Minnesota, USA. ^[3] Department of Pathology and Laboratory Medicine, Emory Vaccine Center, and Yerkes National Primate Research Center. ^[4] Emory Vaccine Center, School of Medicine, Emory University, Atlanta, Georgia, USA. ^[5] Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA. ^[6] New Iberia Research Center, University of Louisiana Lafayette, Lafayette, Louisiana, USA. ^[7] 3M Drug Delivery Systems, Saint Paul, Minnesota, USA. ^[8] Schulich School of Medicine & Dentistry, The University of Western Ontario, London, Ontario, Canada. ^[9] Cellular Biology Section, Laboratory of Viral Diseases, NIAID, NIH, Bethesda, Maryland, USA. ^[10] Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. ^[11] Departments of Pathology, and Microbiology & Immunology, Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, California, USA. ^[12]

医学主题词艾滋病疫苗(AIDS Vaccines);佐剂, 免疫(Adjuvants, Immunologic);动物(Animals);抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);遗传载体(Genetic Vectors);HIV感染(HIV Infections);HIV-1(HIV-1);杂环化合物, 3环(Heterocyclic Compounds, 3-Ring);猕猴(Macaca mulatta);黏膜(Mucous Membrane);猴获得性免疫缺陷综合征(Simian Acquired Immunodeficiency Syndrome);硬脂酸类(Stearic Acids);治疗结果(Treatment Outcome);接种(Vaccination);疫苗, 合成(Vaccines, Synthetic);阴道(Vagina);env基因产物, 人免疫缺陷病毒(env Gene Products, Human Immunodeficiency Virus)

DOI 10.1172/jci.insight.126047

PMID 30830870

发布时间 2024-04-13

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Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.

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Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques.

JCI insight

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JCI insight

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