首页> Nature medicine> Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy.

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第一作者： Meike E W,Logtenberg

第一单位： Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

作者： Meike E W,Logtenberg ^[1] ; J H Marco,Jansen ^[2] ; Matthijs,Raaben ^[3] ; Mireille,Toebes ^[1] ; Katka,Franke ^[4] ; Arianne M,Brandsma ^[2] ; Hanke L,Matlung ^[4] ; Astrid,Fauster ^[3] ; Raquel,Gomez-Eerland ^[5] ; Noor A M,Bakker ^[5] ; Simone,van der Schot ^[1] ; Koen A,Marijt ^[6] ; Martijn,Verdoes ^[7] ; John B A G,Haanen ^[5] ; Joost H,van den Berg ^[5] ; Jacques,Neefjes ^[8] ; Timo K,van den Berg ^[4] ; Thijn R,Brummelkamp ^[3] ; Jeanette H W,Leusen ^[2] ; Ferenc A,Scheeren ^[6] ; Ton N,Schumacher ^[9]

作者单位： Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. ^[1] Laboratory for Translational Immunology, UMC Utrecht, Utrecht, The Netherlands. ^[2] Division of Biochemistry, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. ^[3] Department of Blood Cell Research, Sanquin Research, Landsteiner Laboratory, and Department of Molecular Cell Biology, Amsterdam University Medical Center, Amsterdam, The Netherlands. ^[4] Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. ^[5] Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands. ^[6] Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.;Institute for Chemical Immunology, Amsterdam, The Netherlands. ^[7] Institute for Chemical Immunology, Amsterdam, The Netherlands.;Department of Cell and Chemical Biology, Oncode Institute, Leiden University Medical Center, Leiden, The Netherlands. ^[8] Division of Molecular Oncology and Immunology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands. t.schumacher@nki.nl.;Institute for Chemical Immunology, Amsterdam, The Netherlands. t.schumacher@nki.nl. ^[9]