Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells.

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作者： Nishani,Rajakulendran ^[1] ; Katherine J,Rowland ^[2] ; Hayden J,Selvadurai ^[2] ; Moloud,Ahmadi ^[1] ; Nicole I,Park ^[2] ; Sergey,Naumenko ^[3] ; Sonam,Dolma ^[4] ; Ryan J,Ward ^[5] ; Milly,So ^[2] ; Lilian,Lee ^[2] ; Graham,MacLeod ^[2] ; Clarissa,Pasiliao ^[2] ; Caroline,Brandon ^[1] ; Ian D,Clarke ^[2] ; Michael D,Cusimano ^[3] ; Mark,Bernstein ^[2] ; Nizar,Batada ^[2] ; Stephane,Angers ^[4] ; Peter B,Dirks ^[5]

作者单位： Leslie Dan Faculty of Pharmacy, Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada. ^[1] Developmental and Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada. ^[2] Faculty of Medicine, Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 0A4, Canada. ^[3] Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada. ^[4] St. Michael's Hospital, Toronto, Ontario M5B 1W8, Canada. ^[5] Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada. ^[6] Institute of Genetics and Molecular Medicine, Edinburgh EH4 2XU, United Kingdom. ^[7] Faculty of Medicine, Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada. ^[8] Faculty of Medicine, Department of Surgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada. ^[9] Division of Neurosurgery The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada. ^[10]

关键词 Ascl1 Notch Wnt cancer differentiation glioblastoma neuronal self-renewal