FGF2 induces breast cancer growth through ligand-independent activation and recruitment of ERα and PRBΔ4 isoform to MYC regulatory sequences.

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作者： Sebastián,Giulianelli ^[1] ; Marina,Riggio ^[2] ; Tomas,Guillardoy ^[1] ; Cecilia,Pérez Piñero ^[1] ; María A,Gorostiaga ^[1] ; Gonzalo,Sequeira ^[1] ; Gabriela,Pataccini ^[1] ; María F,Abascal ^[1] ; María F,Toledo ^[1] ; Britta M,Jacobsen ^[1] ; Ana C,Guerreiro ^[3] ; António,Barros ^[4] ; Virginia,Novaro ^[4] ; Fátima L,Monteiro ^[1] ; Francisco,Amado ^[5] ; Hugo,Gass ^[4] ; Martin,Abba ^[6] ; Luisa A,Helguero ^[7] ; Claudia,Lanari ^[5]

作者单位： Instituto de Biología y Medicina Experimental, IByME-CONICET, Buenos Aires, Argentina. ^[1] Instituto de Biología de Organismos Marinos, IBIOMAR-CCT CENPAT-CONICET, Puerto Madryn, Argentina. ^[2] Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. ^[3] Department of Chemistry, QOPNA - Universidade de Aveiro, Aveiro, Portugal. ^[4] Department of Medical Sciences, iBiMED - Universidade de Aveiro, Aveiro, Portugal. ^[5] Hospital de Agudos Magdalena V de Martínez, General Pacheco, Buenos Aires, Argentina. ^[6] CINIBA, Universidad Nacional de La Plata, La Plata, Argentina. ^[7]

关键词 MYC FGF2 PR isoforms PRBΔ4 breast cancer hormone receptor interactions