Discovery of Novel Bromophenol-Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer.
第一作者:
Chuanlong,Guo
第一单位:
Key Laboratory of Experimental Marine Biology , Institute of Oceanology, Chinese Academy of Sciences , Qingdao 266071 , Shandong , China.
作者:
主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);DNA断裂, 双链(DNA Breaks, Double-Stranded);药物发现(Drug Discovery);人类(Humans);过氧化氢(Hydrogen Peroxide);半数抑制浓度(Inhibitory Concentration 50);小鼠(Mice);肿瘤(Neoplasms);酚类(Phenols);活性氧(Reactive Oxygen Species);缩氨硫脲类(Thiosemicarbazones);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1021/acs.jmedchem.8b01946
PMID
30844273
发布时间
2020-03-03
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Journal of medicinal chemistry
3051-3067页
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