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The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation.

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第一作者： Xi,Jin

第一单位： Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.;Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.;Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.

作者： Xi,Jin ^[1] ; Xiao-En,Xu ^[2] ; Yi-Zhou,Jiang ^[2] ; Yi-Rong,Liu ^[1] ; Wei,Sun ^[1] ; Ya-Jie,Guo ^[1] ; Yi-Xing,Ren ^[1] ; Wen-Jia,Zuo ^[2] ; Xin,Hu ^[2] ; Sheng-Lin,Huang ^[3] ; Hong-Jie,Shen ^[4] ; Fei,Lan ^[4] ; Yun-Fei,He ^[5] ; Guo-Hong,Hu ^[5] ; Gen-Hong,Di ^[2] ; Xiang-Huo,He ^[3] ; Da-Qiang,Li ^[3] ; Suling,Liu ^[6] ; Ke-Da,Yu ^[2] ; Zhi-Ming,Shao ^[2]

作者单位： Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.;Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.;Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China. ^[1] Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.;Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.;Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.;Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China. ^[2] Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong-An Road, Shanghai 200032, P. R. China.;Precision Cancer Medicine Center, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.;Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China. ^[3] Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and Key Laboratory of Epigenetics, Department of Cellular and Genetic Medicine, School of Basic Medical Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P. R. China. ^[4] The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P. R. China. ^[5] Department of Breast Surgery, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.;Cancer Institute, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, P. R. China.;Institutes of Biomedical Sciences, Fudan University, Shanghai, P. R. China. ^[6]

医学主题词细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);细胞增殖(Cell Proliferation);疾病恶化(Disease Progression);内源性逆转录病毒(Endogenous Retroviruses);女(雌)性(Female);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);模型, 生物学(Models, Biological);肿瘤转移(Neoplasm Metastasis);蛋白质结合(Protein Binding);RNA干扰(RNA Interference);肿瘤抑制蛋白质类(Tumor Suppressor Proteins)

DOI 10.1126/sciadv.aat9820

PMID 30854423

发布时间 2026-03-27

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The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation.

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The endogenous retrovirus-derived long noncoding RNA TROJAN promotes triple-negative breast cancer progression via ZMYND8 degradation.

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