Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites.

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第一作者： Lu,Su

第一单位： State Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.

作者： Lu,Su ^[1] ; Linkang,Zhou ^[1] ; Feng-Jung,Chen ^[1] ; Huimin,Wang ^[2] ; Hui,Qian ^[1] ; Yuanyuan,Sheng ^[1] ; Yuangang,Zhu ^[2] ; Hua,Yu ^[3] ; Xinqi,Gong ^[4] ; Li'e,Cai ^[5] ; Xuerui,Yang ^[6] ; Li,Xu ^[7] ; Tong-Jin,Zhao ^[1] ; John Zhong,Li ^[8] ; Xiao-Wei,Chen ^[5] ; Peng,Li ^[6]

作者单位： State Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China. ^[1] State Key Laboratory of Membrane Biology, Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, China. ^[2] The First Affiliated Hospital and Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, School of Medicine, Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China. ^[3] Mathematical Intelligence Application Lab, Institute for Mathematical Sciences, Renmin University of China, Beijing, China. ^[4] Key Laboratory of Rare Metabolic Disease, The Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, China. ^[5] Department of Molecular Biology and Biochemistry, Nanjing Medical University, Nanjing, Jiangsu, China. ^[6] MOE Key Laboratory of Bioinformatics, Center for Synthetic & Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China. ^[7] State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian, China. ^[8] State Key Laboratory of Membrane Biology, Center for Life Sciences, Institute of Molecular Medicine, Peking University, Beijing, China xiaowei_chen@pku.edu.cn li-peng@mail.tsinghua.edu.cn. ^[9] State Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China xiaowei_chen@pku.edu.cn li-peng@mail.tsinghua.edu.cn. ^[10]

关键词 SREBP COPII vesicles Cideb fatty liver lipid metabolism