Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases.

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第一作者： Christopher J,Folts

第一单位： Division of Newborn Medicine, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Current address: Vertex Pharmaceuticals, 50 Northern Avenue, Boston, MA 02210, USA.

作者： Christopher J,Folts ^[1] ; Stefanie,Giera ^[2] ; Tao,Li ^[3] ; Xianhua,Piao ^[4]

作者单位： Division of Newborn Medicine, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Current address: Vertex Pharmaceuticals, 50 Northern Avenue, Boston, MA 02210, USA. ^[1] Division of Newborn Medicine, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Current address: Sanofi S.A., 49 New York Avenue, Framingham, MA 01701, USA. ^[2] Division of Newborn Medicine, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA. ^[3] Division of Newborn Medicine, Department of Medicine, Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Newborn Brain Research Institute, University of California at San Francisco, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: xianhua.piao@ucsf.edu. ^[4]

关键词 GAIN domain GPCR Autoproteolysis INducing domain adhesion G protein-coupled receptors neurodevelopment neurological disease

主题词动物(Animals);人类(Humans);分子靶向治疗(Molecular Targeted Therapy);突变(Mutation);神经系统疾病(Nervous System Diseases);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);信号传导(Signal Transduction)

DOI 10.1016/j.tips.2019.02.003

PMID 30871735

发布时间 2020-04-01

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