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首页> Biomaterials> MSC-derived sEVs enhance patency and inhibit calcification of synthetic vascular grafts by immunomodulation in a rat model of hyperlipidemia.

MSC-derived sEVs enhance patency and inhibit calcification of synthetic vascular grafts by immunomodulation in a rat model of hyperlipidemia.

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作者： Yongzhen,Wei ^[1] ; Yifan,Wu ^[1] ; Runxia,Zhao ^[1] ; Kaiyue,Zhang ^[2] ; Adam C,Midgley ^[1] ; Deling,Kong ^[1] ; Zongjin,Li ^[3] ; Qiang,Zhao ^[4]

作者单位： State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, PR China. ^[1] Nankai University School of Medicine, Tianjin 300071, PR China. ^[2] Nankai University School of Medicine, Tianjin 300071, PR China. Electronic address: zongjinli@nankai.edu.cn. ^[3] State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, PR China. Electronic address: qiangzhao@nankai.edu.cn. ^[4]

关键词 Calcification Hyperlipidemia Immunomodulation Small extracellular vesicles (sEVs)Tissue regeneration Vascular grafts

主题词动物(Animals);消炎药(Anti-Inflammatory Agents);血管假体植入(Blood Vessel Prosthesis Implantation);钙质沉着症(Calcinosis);疾病模型, 动物(Disease Models, Animal);基因表达调控(Gene Expression Regulation);肝素(Heparin);人类(Humans);高脂血症(Hyperlipidemias);免疫调节(Immunomodulation);巨噬细胞(Macrophages);间质干细胞(Mesenchymal Stem Cells);表型(Phenotype);多酯类(Polyesters);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);再生(Regeneration);组织支架(Tissue Scaffolds);血管移植术(Vascular Grafting);血管未闭(Vascular Patency)

DOI 10.1016/j.biomaterials.2019.01.049

PMID 30875515

发布时间 2020-08-28

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Biomaterials

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