Introduction of Nonacidic Side Chains on 6-Ethylcholane Scaffolds in the Identification of Potent Bile Acid Receptor Agonists with Improved Pharmacokinetic Properties.

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第一作者： Claudia,Finamore

第一单位： Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy. claudia.finamore@unina.it.

作者： Claudia,Finamore ^[1] ; Giuliana,Baronissi ^[2] ; Silvia,Marchianò ^[3] ; Francesco Saverio,Di Leva ^[4] ; Adriana,Carino ^[5] ; Maria Chiara,Monti ^[6] ; Vittorio,Limongelli ^[7] ; Angela,Zampella ^[8] ; Stefano,Fiorucci ^[9] ; Valentina,Sepe ^[10]

作者单位： Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy. claudia.finamore@unina.it. ^[1] Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy. giuliana.baronissi@unina.it. ^[2] Department of Surgery and Biomedical Sciences, Nuova Facoltà di Medicina, Piazza Lucio Severi, 1 - 06132 Perugia, Italy. silvia4as@hotmail.it. ^[3] Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy. francesco.dileva@unina.it. ^[4] Department of Surgery and Biomedical Sciences, Nuova Facoltà di Medicina, Piazza Lucio Severi, 1 - 06132 Perugia, Italy. adriana.carino@hotmail.it. ^[5] Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Salerno, Italy. mcmonti@unisa.it. ^[6] Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy. vittoriolimongelli@gmail.com. ^[7] Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute of Computational Science - Center for Computational Medicine in Cardiology, Via G. Buffi 13, CH-6900 Lugano, Switzerland. vittoriolimongelli@gmail.com. ^[8] Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy. azampell@unina.it. ^[9] Department of Surgery and Biomedical Sciences, Nuova Facoltà di Medicina, Piazza Lucio Severi, 1 - 06132 Perugia, Italy. stefano.fiorucci@unipg.it. ^[10] Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy. valentina.sepe@unina.it. ^[11]

关键词 FXR agonists bile acid receptors medicinal chemistry steroidal scaffolds