LPLUNC1 stabilises PHB1 by counteracting TRIM21-mediated ubiquitination to inhibit NF-κB activity in nasopharyngeal carcinoma.
第一作者:
Heran,Wang
第一单位:
Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, 283 Tongzipo Road, Changsha, 410013, Hunan, China.
作者:
主题词
成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);动物(Animals);自身抗原(Autoantigens);细胞系, 肿瘤(Cell Line, Tumor);脂肪酸结合蛋白质类(Fatty Acid-Binding Proteins);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);基因, 肿瘤抑制(Genes, Tumor Suppressor);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);中年人(Middle Aged);NF-κB(NF-kappa B);鼻咽肿瘤(Nasopharyngeal Neoplasms);蛋白质加工, 转译后(Protein Processing, Post-Translational);蛋白质稳定性(Protein Stability);阻遏蛋白质类(Repressor Proteins);核糖核蛋白类(Ribonucleoproteins);信号传导(Signal Transduction);泛素化(Ubiquitination)
DOI
10.1038/s41388-019-0778-6
PMID
30886235
发布时间
2022-04-20
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Oncogene
5062-5075页
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