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Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis.

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第一作者： Jiqing,Cao

第一单位： Research and Development, James J Peters VA Medical Center, Bronx, NY 10468, United States; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; The Central Hospital of The Hua Zhong University of Science and Technology, Wuhan, China. Electronic address: jiqing.cao@mssm.edu.

作者： Jiqing,Cao ^[1] ; Margaret B,Zhong ^[2] ; Carlos A,Toro ^[3] ; Larry,Zhang ^[4] ; Dongming,Cai ^[5]

作者单位： Research and Development, James J Peters VA Medical Center, Bronx, NY 10468, United States; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; The Central Hospital of The Hua Zhong University of Science and Technology, Wuhan, China. Electronic address: jiqing.cao@mssm.edu. ^[1] Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; Barnard College of Columbia University, New York, NY 10027, United States. Electronic address: mbz2111@barnard.edu. ^[2] Research and Development, James J Peters VA Medical Center, Bronx, NY 10468, United States; National Center for the Medical Consequences of Spinal Cord Injury, James J Peters VA Medical Center, Bronx, NY 10468, United States; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address: carlos.toro@mssm.edu. ^[3] Research and Development, James J Peters VA Medical Center, Bronx, NY 10468, United States; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address: lazh360@gmail.com. ^[4] Research and Development, James J Peters VA Medical Center, Bronx, NY 10468, United States; Neurology Section, James J Peters VA Medical Center, Bronx, NY 10468, United States; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States; The Central Hospital of The Hua Zhong University of Science and Technology, Wuhan, China. Electronic address: dongming.cai@mssm.edu. ^[5]

关键词 Alzheimer's disease Endo-lysosomal dysregulation Impaired autophagy Pathogenesis Proteostasis Ubiquitin-proteasome system

医学主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);动物(Animals);自噬(Autophagy);内颗粒(Endosomes);人类(Humans);溶酶体(Lysosomes);蛋白酶体内肽酶复合物(Proteasome Endopeptidase Complex);信号传导(Signal Transduction);泛素(Ubiquitin);tau蛋白质类(tau Proteins)

DOI 10.1016/j.neulet.2019.03.016

PMID 30890471

发布时间 2024-07-20

基金项目

RF1 AG054014/AG/NIA NIH HHS/United States I01 BX003380/BX/BLRD VA/United States I01 RX002290/RX/RRD VA/United States R56 AG058655/AG/NIA NIH HHS/United States R01 AG048923/AG/NIA NIH HHS/United States

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