Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.

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作者： James J-W,Duan ^[1] ; Zhonghui,Lu ^[1] ; Bin,Jiang ^[1] ; Sylwia,Stachura ^[1] ; Carolyn A,Weigelt ^[1] ; John S,Sack ^[1] ; Javed,Khan ^[1] ; Max,Ruzanov ^[1] ; Michael A,Galella ^[1] ; Dauh-Rurng,Wu ^[1] ; Melissa,Yarde ^[1] ; Ding-Ren,Shen ^[1] ; David J,Shuster ^[1] ; Virna,Borowski ^[1] ; Jenny H,Xie ^[1] ; Lisa,Zhang ^[1] ; Sridhar,Vanteru ^[2] ; Arun Kumar,Gupta ^[2] ; Arvind,Mathur ^[1] ; Qihong,Zhao ^[1] ; William,Foster ^[1] ; Luisa M,Salter-Cid ^[1] ; Percy H,Carter ^[1] ; T G Murali,Dhar ^[1]

作者单位： Research and Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543-4000, United States. ^[1] Bristol-Myers Squibb-Biocon Research Center, Bangalore 560099, India. ^[2]

DOI 10.1021/acsmedchemlett.9b00010

PMID 30891142

发布时间 2020-09-28

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ACS medicinal chemistry letters

2019年10卷3期

367-373页

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Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.

ACS medicinal chemistry letters

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ACS medicinal chemistry letters

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Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.

ACS medicinal chemistry letters

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ACS medicinal chemistry letters

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