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Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation.

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第一作者： Quentin,Spillier

第一单位： Medicinal Chemistry Research Group (CMFA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain, B-1200, Brussels, Belgium.;Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, B-1200, Brussels, Belgium.

作者： Quentin,Spillier ^[1] ; Didier,Vertommen ^[2] ; Séverine,Ravez ^[3] ; Romain,Marteau ^[4] ; Quentin,Thémans ^[5] ; Cyril,Corbet ^[6] ; Olivier,Feron ^[6] ; Johan,Wouters ^[5] ; Raphaël,Frédérick ^[7]

作者单位： Medicinal Chemistry Research Group (CMFA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain, B-1200, Brussels, Belgium.;Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, B-1200, Brussels, Belgium. ^[1] de Duve Institute, Université catholique de Louvain, B-1200, Brussels, Belgium. ^[2] UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Université de Lille, Inserm, CHU Lille, F-59000, Lille, France. ^[3] Medicinal Chemistry Research Group (CMFA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain, B-1200, Brussels, Belgium. ^[4] Department of Chemistry, NAmur MEdicine & Drug Innovation Center (NAMEDIC-NARILIS), Université de Namur, 61 rue de Bruxelles, B-5000, Namur, Belgium. ^[5] Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, B-1200, Brussels, Belgium. ^[6] Medicinal Chemistry Research Group (CMFA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain, B-1200, Brussels, Belgium. raphael.frederick@uclouvain.be. ^[7]