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首页> Life sciences> HIV-1 Nef physically associate with CAMKIIδ - ASK-1 complex to inhibit p38MAPK signalling and apoptosis in infected cells.

HIV-1 Nef physically associate with CAMKIIδ - ASK-1 complex to inhibit p38MAPK signalling and apoptosis in infected cells.

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作者： Pradeep,Kumar ^[1] ; Kavita,Rawat ^[1] ; Tanuj,Sharma ^[2] ; Sushila,Kumari ^[1] ; Reshu,Saxena ^[1] ; Balawant,Kumar ^[1] ; Tanvi,Baghel ^[1] ; Tayyaba,Afshan ^[2] ; Mohammad Imran,Siddiqi ^[2] ; Aamir,Nazir ^[1] ; Jimut Kanti,Ghosh ^[2] ; Raj Kamal,Tripathi ^[3]

作者单位： Division of Toxicology and Experimental Medicine, Central Drug Research Institute, Council of Scientific & Industrial Research, BS-10/1, Sector-10 Jankipuram Extension, Uttar Pradesh, India. ^[1] Division of Molecular and Structural Biology, Central Drug Research Institute, Council of Scientific & Industrial Research, BS-10/1, Sector-10 Jankipuram Extension, Uttar Pradesh, India. ^[2] Division of Toxicology and Experimental Medicine, Central Drug Research Institute, Council of Scientific & Industrial Research, BS-10/1, Sector-10 Jankipuram Extension, Uttar Pradesh, India.. Electronic address: rk_tripathi@cdri.res.in. ^[3]

关键词 ASK-1 Apoptosis CAMKIIδ Calcium influx HIV-1 Nef Protein-protein interaction p38MAPK

主题词细胞凋亡(Apoptosis);钙-钙调素依赖性蛋白激酶2型(Calcium-Calmodulin-Dependent Protein Kinase Type 2);HEK293细胞(HEK293 Cells);HIV感染(HIV Infections);HIV-1(HIV-1);人类(Humans);Jurkat细胞(Jurkat Cells);MAP激酶激酶激酶5(MAP Kinase Kinase Kinase 5);磷酰化(Phosphorylation);蛋白质结合(Protein Binding);蛋白质构象(Protein Conformation);信号传导(Signal Transduction);nef基因产物, 人免疫缺陷病毒(nef Gene Products, Human Immunodeficiency Virus);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)

DOI 10.1016/j.lfs.2019.03.039

PMID 30902545

发布时间 2019-05-20

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