作者：
Yunyun,Yang [1]
;
Liping,Li [1]
;
Linjie,Yuan [1]
;
Xiaoying,Zhou [1]
;
Jianxin,Duan [2]
;
Hongying,Xiao [3]
;
Ningning,Cai [4]
;
Shuai,Han [1]
;
Xianqiang,Ma [1]
;
Weidong,Liu [5]
;
Chun-Chi,Chen [5]
;
Lingle,Wang [6]
;
Xin,Li [3]
;
Jiahuan,Chen [7]
;
Ning,Kang [7]
;
Jing,Chen [7]
;
Zhixun,Shen [7]
;
Satish R,Malwal [8]
;
Wanli,Liu [7]
;
Yan,Shi [7]
;
Eric,Oldfield [9]
;
Rey-Ting,Guo [10]
;
Yonghui,Zhang [11]
作者单位：
School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.
[1]
Schrödinger, GmbH, Q7 23, 681 61 Mannheim, Germany.
[2]
School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China; Joint Graduate Program of Peking-Tsinghua-NIBS, School of Life Sciences, Tsinghua University, Beijing 100084, China.
[3]
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China.
[4]
State Key Laboratory of Bio-catalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, Wuhan 430062, China.
[5]
Schrödinger, Inc., 120 West 45(th) Street, New York, NY 10036, USA.
[6]
Institute of Immunology, Tsinghua University, Beijing 100084, China.
[7]
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
[8]
Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address: eoldfiel@illinois.edu.
[9]
State Key Laboratory of Bio-catalysis and Enzyme Engineering, Hubei Collaborative Innovation Center for Green Transformation of Bio-Resources, School of Life Sciences, Hubei University, Wuhan 430062, China. Electronic address: guoreyting@gmail.com.
[10]
School of Pharmaceutical Sciences, Beijing Advanced Innovation Center for Structural Biology, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China. Electronic address: zhangyonghui@tsinghua.edu.cn.
[11]
主题词
抗原, CD(Antigens, CD);结合部位(Binding Sites);结晶学, X线(Crystallography, X-Ray);二聚作用(Dimerization);药物设计(Drug Design);人类(Humans);氢键合(Hydrogen Bonding);免疫疗法(Immunotherapy);淋巴细胞活化(Lymphocyte Activation);模型, 分子(Models, Molecular);分子动力学模拟(Molecular Dynamics Simulation);诱变, 定点(Mutagenesis, Site-Directed);蛋白质构象(Protein Conformation);蛋白质亚型(Protein Isoforms);蛋白质加工, 转译后(Protein Processing, Post-Translational);受体, 抗原, T细胞, γ-δ(Receptors, Antigen, T-Cell, gamma-delta);单细胞分析(Single-Cell Analysis);构效关系(Structure-Activity Relationship);T淋巴细胞亚群(T-Lymphocyte Subsets)
DOI
10.1016/j.immuni.2019.02.016
PMID
30902636
发布时间
2019-09-16
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