Aurora A Inhibition Eliminates Myeloid Cell-Mediated Immunosuppression and Enhances the Efficacy of Anti-PD-L1 Therapy in Breast Cancer.

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第一作者： Tingting,Yin

第一单位： Department of General Surgery of the First Affiliated Hospital, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

作者： Tingting,Yin ^[1] ; Zhi-Bin,Zhao ^[2] ; Jing,Guo ^[1] ; Tianchen,Wang ^[1] ; Jing-Bo,Yang ^[1] ; Chao,Wang ^[1] ; Jie,Long ^[2] ; Shisong,Ma ^[1] ; Qiang,Huang ^[3] ; Kaiguang,Zhang ^[4] ; Xiaopeng,Ma ^[4] ; Chenhai,Liu ^[4] ; Suling,Liu ^[5] ; Zhe-Xiong,Lian ^[6] ; Zhenye,Yang ^[7]

作者单位： Department of General Surgery of the First Affiliated Hospital, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. ^[1] Chronic Disease Laboratory, Institutes for Life Sciences and School of Medicine, South China University of Technology, Guangzhou, China. ^[2] The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, Hefei, China.;Department of General Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei, China. ^[3] The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital, Hefei, China. ^[4] Key Laboratory of Breast Cancer in Shanghai, Cancer Institute, Department of Breast Surgery, Institutes of Biomedical Sciences, Innovation Center for Cell Signaling Network, Fudan University Shanghai Cancer Center, Shanghai, China. ^[5] Chronic Disease Laboratory, Institutes for Life Sciences and School of Medicine, South China University of Technology, Guangzhou, China. zhenye@ustc.edu.cn zxlian@scut.edu.cn. ^[6] Department of General Surgery of the First Affiliated Hospital, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China. zhenye@ustc.edu.cn zxlian@scut.edu.cn. ^[7]

主题词动物(Animals);乳腺肿瘤(Breast Neoplasms);人类(Humans);小鼠(Mice);髓系细胞(Myeloid Cells);肿瘤微环境(Tumor Microenvironment)

DOI 10.1158/0008-5472.CAN-18-3397

PMID 30902796

发布时间 2019-08-26

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