PON1 is a disease modifier gene in amyotrophic lateral sclerosis: association of the Q192R polymorphism with bulbar onset and reduced survival.

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作者： Federico,Verde ^[1] ; Cinzia,Tiloca ^[2] ; Claudia,Morelli ^[2] ; Alberto,Doretti ^[2] ; Barbara,Poletti ^[2] ; Luca,Maderna ^[2] ; Stefano,Messina ^[2] ; Davide,Gentilini ^[3] ; Isabella,Fogh ^[4] ; Antonia,Ratti ^[2] ; Vincenzo,Silani ^[5] ; Nicola,Ticozzi ^[2]

作者单位： Department of Neurology - Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano, IRCCS, Piazzale Brescia 20, 20149, Milan, Italy. fdrc.verde@gmail.com. ^[1] Department of Neurology - Stroke Unit and Laboratory of Neuroscience, Istituto Auxologico Italiano, IRCCS, Piazzale Brescia 20, 20149, Milan, Italy. ^[2] Unit of Bioinformatics and Genomic Statistics, Istituto Auxologico Italiano, IRCCS, Via Zucchi 18, 20095, Cusano Milanino, Italy. ^[3] Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy. ^[4] Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK. ^[5] Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, via Vanvitelli 32, 20129, Milan, Italy. ^[6] Department of Pathophysiology and Transplantation, "Dino Ferrari" Center, Università degli Studi di Milano, Via Francesco Sforza 35, 20122, Milan, Italy. ^[7] "Aldo Ravelli" Center for Neurotechnology and Experimental Brain Therapeutics, Università degli Studi di Milano, via Festa del Perdono 7, 20122, Milan, Italy. ^[8]

关键词 ALS Motor neurons PON1 Paraoxonase SNP Toxicity