The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk.

导出原文传递

翻译打印收藏纠错

第一作者： Olivia,Belbin

第一单位： Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.;Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain.

作者： Olivia,Belbin ^[1] ; Kevin,Morgan ^[2] ; Chris,Medway ^[3] ; Donald,Warden ^[4] ; Mario,Cortina-Borja ^[5] ; Cornelia M,van Duijn ^[6] ; Hieab H H,Adams ^[6] ; Ana,Frank-Garcia ^[7] ; Keeley,Brookes ^[2] ; Pascual,Sánchez-Juan ^[8] ; Victoria,Alvarez ^[9] ; Reinhard,Heun ^[10] ; Heike,Kölsch ^[10] ; Eliecer,Coto ^[9] ; Patrick G,Kehoe ^[11] ; Eloy,Rodriguez-Rodriguez ^[8] ; Maria J,Bullido ^[7] ; M Arfan,Ikram ^[6] ; A David,Smith ^[4] ; Donald J,Lehmann ^[4]

作者单位： Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.;Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain. ^[1] Human Genetics School of Life Sciences, University of Nottingham, UK. ^[2] Institute of Medical Genetics, University Hospital Wales, Cardiff, UK. ^[3] Oxford Project to Investigate Memory and Ageing (OPTIMA), University Department of Pharmacology, Oxford, UK. ^[4] Clinical Epidemiology, Nutrition and Biostatistics, UCL Great Ormond Street Institute of Child Health, London, UK. ^[5] Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. ^[6] Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain.;Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain. ^[7] Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain.;Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain. ^[8] Laboratorio de Genética, AGC Laboratorio de Medicina, Hospital Universitario Central de Asturias, Oviedo, Spain. ^[9] Department of Psychiatry, University of Bonn, Bonn, Germany. ^[10] Dementia Research Group, Bristol Medical School Translational Health Sciences, University of Bristol, Southmead Hospital, Bristol, UK. ^[11]

关键词 Alzheimer’s disease Sortilin brain-derived neurotrophic factor dopamine beta-hydroxylase epistasis genetics neurotrophins