Complement C4 Prevents Viral Infection through Capsid Inactivation.

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第一作者： Maria,Bottermann

第一单位： Protein and Nucleic Acid Chemistry Division, Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, UK.

作者： Maria,Bottermann ^[1] ; Stian,Foss ^[2] ; Sarah L,Caddy ^[1] ; Dean,Clift ^[1] ; Laurens M,van Tienen ^[1] ; Marina,Vaysburd ^[1] ; James,Cruickshank ^[1] ; Kevin,O'Connell ^[1] ; Jessica,Clark ^[1] ; Keith,Mayes ^[1] ; Katie,Higginson ^[1] ; Heidrun E,Lode ^[3] ; Martin B,McAdam ^[4] ; Inger,Sandlie ^[5] ; Jan Terje,Andersen ^[3] ; Leo C,James ^[6]

作者单位： Protein and Nucleic Acid Chemistry Division, Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. ^[1] Centre for Immune Regulation (CIR) and Department of Biosciences, University of Oslo, Oslo N-0316, Norway; CIR and Department of Immunology, Rikshospitalet, Oslo University Hospital, Oslo N-0372, Norway; Department of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo N-0372, Norway. ^[2] CIR and Department of Immunology, Rikshospitalet, Oslo University Hospital, Oslo N-0372, Norway; Department of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Oslo N-0372, Norway. ^[3] CIR and Department of Immunology, Rikshospitalet, Oslo University Hospital, Oslo N-0372, Norway. ^[4] Centre for Immune Regulation (CIR) and Department of Biosciences, University of Oslo, Oslo N-0316, Norway; CIR and Department of Immunology, Rikshospitalet, Oslo University Hospital, Oslo N-0372, Norway. ^[5] Protein and Nucleic Acid Chemistry Division, Medical Research Council, Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: lcj@mrc-lmb.cam.ac.uk. ^[6]

关键词 TRIM21 adenovirus complement complement C4 complement-mediated neutralization gene therapy host-pathogen humoral immunity neutralizing antibodies non-enveloped virus