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首页> Cancer chemotherapy and pharmacology> The combination of olaratumab with gemcitabine and docetaxel arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft mouse model.

The combination of olaratumab with gemcitabine and docetaxel arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft mouse model.

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作者： Takashi,Higuchi ^[1] ; Kentaro,Miyake ^[2] ; Norihiko,Sugisawa ^[3] ; Hiromichi,Oshiro ^[1] ; Zhiying,Zhang ^[2] ; Sahar,Razmjooei ^[1] ; Norio,Yamamoto ^[2] ; Katsuhiro,Hayashi ^[1] ; Hiroaki,Kimura ^[2] ; Shinji,Miwa ^[1] ; Kentaro,Igarashi ^[2] ; Michael,Bouvet ^[1] ; Shree Ram,Singh ^[3] ; Hiroyuki,Tsuchiya ^[3] ; Robert M,Hoffman ^[3]

作者单位： AntiCancer, Inc., San Diego, CA, USA. ^[1] Department of Surgery, University of California, San Diego, CA, USA. ^[2] Department of Orthopedic Surgery, Kanazawa University, Kanazawa, Japan. ^[3] Basic Research Laboratory, National Cancer Institute, Frederick, MD, USA. singhshr@mail.nih.gov. ^[4] Department of Orthopedic Surgery, Kanazawa University, Kanazawa, Japan. tsuchi@med.kanazawa-u.ac.jp. ^[5] AntiCancer, Inc., San Diego, CA, USA. all@anticancer.com. ^[6] Department of Surgery, University of California, San Diego, CA, USA. all@anticancer.com. ^[7]

关键词 Docetaxel Doxorubicin Gemcitabine Olaratumab PDOX Patient-derived orthotopic xenograft Undifferentiated soft-tissue sarcoma

主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);抗肿瘤联合化疗方案(Antineoplastic Combined Chemotherapy Protocols);脱氧胞苷(Deoxycytidine);抗药性, 肿瘤(Drug Resistance, Neoplasm);女(雌)性(Female);人类(Humans);小鼠(Mice);小鼠, 裸(Mice, Nude);中年人(Middle Aged);肉瘤(Sarcoma);治疗结果(Treatment Outcome);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1007/s00280-019-03824-3

PMID 30929053

发布时间 2022-12-07

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Cancer chemotherapy and pharmacology

Cancer chemotherapy and pharmacology

2019年83卷6期

1075-1082页

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