Loss of PDZK1 expression activates PI3K/AKT signaling via PTEN phosphorylation in gastric cancer.

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作者： Chunjuan,Zhao ^[1] ; Tao,Tao ^[1] ; Longyan,Yang ^[2] ; Qiong,Qin ^[3] ; Ying,Wang ^[1] ; Hua,Liu ^[1] ; Ran,Song ^[1] ; Xiaomei,Yang ^[1] ; Qiqi,Wang ^[1] ; Siyu,Gu ^[1] ; Ying,Xiong ^[1] ; Dong,Zhao ^[2] ; Songlin,Wang ^[1] ; Duiping,Feng ^[4] ; Wen G,Jiang ^[5] ; Jun,Zhang ^[6] ; Junqi,He ^[7]

作者单位： Beijing Key Laboratory for Tumor Invasion and Metastasis, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, 100069, Beijing, China. ^[1] Department of Endocrinology, Beijing Luhe Hospital, Capital Medical University, 101149, Beijing, China. ^[2] Beijing Key Laboratory for Tumor Invasion and Metastasis, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, 100069, Beijing, China. Electronic address: qqin@ccmu.edu.cn. ^[3] Department of Interventional Radiology, First Hospital of Shanxi Medical University, 030001, Taiyuan, China. ^[4] Cardiff China Medical Research Collaborative, Cardiff University School of Medicine, Health Park, Cardiff, CF14 4XN, UK. ^[5] Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, 100050, Beijing, China. Electronic address: zhangjundoctor@126.com. ^[6] Beijing Key Laboratory for Tumor Invasion and Metastasis, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, 100069, Beijing, China. Electronic address: jq_he@ccmu.edu.cn. ^[7]

关键词 Carcinogenesis Gastric cancer NHERF3 PDZ PTEN Phosphorylation