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Molecular Basis of Broad Spectrum <i>N</i>-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.

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作者单位: Institute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.;Institute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.;Institute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States. [1] Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Spain. [2] Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland 21201, United States. [3] Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, United States. [4] Institute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States. [5] Institute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.;Photon Science, Deutsches Elektronen-Synchrotron, Hamburg 22607, Germany. [6] Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Spain.;IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain. [7] Institute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.;Institute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.;Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States. [8]
DOI 10.1021/acscentsci.8b00917
PMID 30937380
发布时间 2024-09-22
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ACS central science

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