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Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha.

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第一作者： Claudia,Schubert

第一单位： Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Germany.

作者： Claudia,Schubert ^[1] ; Manuel,Allhoff ^[2] ; Stefan,Tillmann ^[1] ; Tiago,Maié ^[2] ; Ivan G,Costa ^[2] ; Daniel B,Lipka ^[3] ; Mirle,Schemionek ^[1] ; Kristina,Feldberg ^[1] ; Julian,Baumeister ^[1] ; Tim H,Brümmendorf ^[1] ; Nicolas,Chatain ^[1] ; Steffen,Koschmieder ^[4]

作者单位： Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Germany. ^[1] Institute for Computational Genomics, Faculty of Medicine, RWTH Aachen University, Aachen, Germany. ^[2] Regulation of Cellular Differentiation Group, Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[3] Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Pauwelsstr 30, 52074, Aachen, Germany. skoschmieder@ukaachen.de. ^[4]

关键词 BCR-ABL CRISPR/Cas9 Chronic myeloid leukemia IFNa ISG JAK2V617F MPN Polycythemia vera STAT factors