首页> Cell reports> Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes.

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes.

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第一作者： Matthew J,Harms

第一单位： Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden.

作者： Matthew J,Harms ^[1] ; Qian,Li ^[2] ; Sunjae,Lee ^[3] ; Cheng,Zhang ^[3] ; Bengt,Kull ^[1] ; Stefan,Hallen ^[1] ; Anders,Thorell ^[4] ; Ida,Alexandersson ^[1] ; Carolina E,Hagberg ^[5] ; Xiao-Rong,Peng ^[1] ; Adil,Mardinoglu ^[6] ; Kirsty L,Spalding ^[7] ; Jeremie,Boucher ^[8]

作者单位： Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden. ^[1] Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm 17177, Sweden. ^[2] Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm 17121, Sweden. ^[3] Department of Clinical Sciences, Danderyds Hospital, Karolinska Institutet and Department of Surgery, Ersta Hospital, Stockholm 11691, Sweden. ^[4] Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden. ^[5] Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm 17121, Sweden; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 9RT, United Kingdom. ^[6] Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm 17177, Sweden; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden. ^[7] Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden; The Lundberg Laboratory for Diabetes Research, University of Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Sweden. Electronic address: jeremie.boucher@astrazeneca.com. ^[8]

关键词 BAT MAAC UCP1 WAT adipocyte brown adipose culture transdifferentiation white adipose