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A Step-by-Step Guide to Using BioNetFit.

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第一作者： William S,Hlavacek

第一单位： Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA.

作者： William S,Hlavacek ^[1] ; Jennifer A,Csicsery-Ronay ^[2] ; Lewis R,Baker ^[3] ; María Del Carmen,Ramos Álamo ^[1] ; Alexander,Ionkov ^[2] ; Eshan D,Mitra ^[1] ; Ryan,Suderman ^[4] ; Keesha E,Erickson ^[1] ; Raquel,Dias ^[5] ; Joshua,Colvin ^[5] ; Brandon R,Thomas ^[5] ; Richard G,Posner ^[6]

作者单位： Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA. ^[1] Theoretical Biology and Biophysics Group, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM, USA. ^[2] Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, USA.;Department of Applied Mathematics, University of Colorado, Boulder, CO, USA. ^[3] Theoretical Biology and Biophysics Group, Theoretical Division and Center for Nonlinear Studies, Los Alamos National Laboratory, Los Alamos, NM, USA.;Immunetrics, Inc., Pittsburgh, PA, USA. ^[4] Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, USA. ^[5] Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, USA. richard.posner@nau.edu. ^[6]

关键词 Confidence level Genetic algorithm (GA)Model calibration Network-free simulation Nonlinear least squares fitting Ordinary differential equations (ODEs)Parameter estimation Parameter uncertainty Rule-based modeling Stochastic simulation algorithm (SSA)

医学主题词算法(Algorithms);计算生物学(Computational Biology);计算机模拟(Computer Simulation);模型, 生物学(Models, Biological);软件(Software);系统生物学(Systems Biology)

DOI 10.1007/978-1-4939-9102-0_18

PMID 30945257

发布时间 2020-07-22

基金项目

R01 GM111510/GM/NIGMS NIH HHS/United States

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