Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1.-论文-万方医学网

第一作者： Akira,Kaieda

第一单位： Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan.

作者： Akira,Kaieda ^[1] ; Masashi,Takahashi ^[1] ; Hiromi,Fukuda ^[1] ; Rei,Okamoto ^[1] ; Shinji,Morimoto ^[1] ; Masayuki,Gotoh ^[1] ; Takahiro,Miyazaki ^[1] ; Yuri,Hori ^[1] ; Satoko,Unno ^[1] ; Tomohiro,Kawamoto ^[1] ; Toshimasa,Tanaka ^[1] ; Sachiko,Itono ^[1] ; Terufumi,Takagi ^[1] ; Hiroshi,Sugimoto ^[1] ; Kengo,Okada ^[1] ; Gyorgy,Snell ^[2] ; Ryan,Bertsch ^[2] ; Jasmine,Nguyen ^[2] ; Bi-Ching,Sang ^[2] ; Seiji,Miwatashi ^[1]

作者单位： Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan. ^[1] Takeda California, 10410 Science Center Drive, San Diego, CA, 92121, USA. ^[2]

医学主题词动物(Animals);抗肿瘤药(Antineoplastic Agents);血细胞(Blood Cells);细胞系, 肿瘤(Cell Line, Tumor);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);人类(Humans);氢键合(Hydrogen Bonding);咪唑类(Imidazoles);白细胞介素8(Interleukin-8);脂多糖类(Lipopolysaccharides);模型, 分子(Models, Molecular);分子结构(Molecular Structure);蛋白质结合(Protein Binding);蛋白激酶抑制剂(Protein Kinase Inhibitors);吡啶类(Pyridines);吡啶酮类(Pyridones);大鼠(Rats);构效关系(Structure-Activity Relationship);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)

DOI 10.1002/cmdc.201900129

PMID 30945818

发布时间 2020-05-21

检索历史清除

Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1.

ChemMedChem

相似文献

同项目论文

ChemMedChem

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridin-2-one-Based p38 MAP Kinase Inhibitors: Part 1.

ChemMedChem

相似文献

同项目论文

ChemMedChem

相关期刊

检索历史清除