Recombinant Production of MFHR1, A Novel Synthetic Multitarget Complement Inhibitor, in Moss Bioreactors.

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第一作者： Oguz,Top

第一单位： Department of Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany.;Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany.

作者： Oguz,Top ^[1] ; Juliana,Parsons ^[2] ; Lennard L,Bohlender ^[2] ; Stefan,Michelfelder ^[3] ; Phillipp,Kopp ^[2] ; Christian,Busch-Steenberg ^[2] ; Sebastian N W,Hoernstein ^[2] ; Peter F,Zipfel ^[4] ; Karsten,Häffner ^[3] ; Ralf,Reski ^[5] ; Eva L,Decker ^[2]

作者单位： Department of Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany.;Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany. ^[1] Department of Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany. ^[2] Faculty of Medicine, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University Freiburg, University of Freiburg, Freiburg, Germany. ^[3] Leibniz Institute for Natural Product Research and Infection Biology, Friedrich Schiller University, Jena, Germany. ^[4] Department of Plant Biotechnology, Faculty of Biology, University of Freiburg, Freiburg, Germany.;Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany.;Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. ^[5]

关键词 C3 glomerulopathy Physcomitrella patens aHUS alternative pathway of complement activation factor H moss bioreactor plant-made recombinant pharmaceuticals synthetic complement inhibitor

DOI 10.3389/fpls.2019.00260

PMID 30949184

发布时间 2020-09-30

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