The Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) Protocol: a prospective, multi-center, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.

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第一作者： David N,Hager

第一单位： Division of Pulmonary & Critical Care Medicine, Department of Medicine, Johns Hopkins Hospital, Johns Hopkins University, 1800 Orleans Street, Suite 9121, Baltimore, MD, 21287, USA. dhager1@jhmi.edu.

作者： David N,Hager ^[1] ; Michael H,Hooper ^[2] ; Gordon R,Bernard ^[3] ; Laurence W,Busse ^[4] ; E Wesley,Ely ^[5] ; Alpha A,Fowler ^[6] ; David F,Gaieski ^[7] ; Alex,Hall ^[8] ; Jeremiah S,Hinson ^[9] ; James C,Jackson ^[10] ; Gabor D,Kelen ^[11] ; Mark,Levine ^[12] ; Christopher J,Lindsell ^[5] ; Richard E,Malone ^[6] ; Anna,McGlothlin ^[7] ; Richard E,Rothman ^[13] ; Kert,Viele ^[12] ; David W,Wright ^[14] ; Jonathan E,Sevransky ^[15] ; Greg S,Martin ^[16]

作者单位： Division of Pulmonary & Critical Care Medicine, Department of Medicine, Johns Hopkins Hospital, Johns Hopkins University, 1800 Orleans Street, Suite 9121, Baltimore, MD, 21287, USA. dhager1@jhmi.edu. ^[1] Division of Pulmonary & Critical Care Medicine, Department of Medicine, Eastern Virginia Medical School and Sentara Healthcare, Norfolk, VA, USA. ^[2] Division of Pulmonary & Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA. ^[3] Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University, Atlanta, GA, USA. ^[4] Division of Pulmonary & Critical Care, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. ^[5] Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Vanderbilt University Medical Center, Nashville, TN, USA. ^[6] Tennessee Valley Veteran's Affairs Geriatric Research Education Clinical Center (GRECC), Nashville, TN, USA. ^[7] Division of Pulmonary Disease & Critical Care Medicine, Department of Internal Medicine, The VCU Johnson Center for Critical Care and Pulmonary Research, Virginia Commonwealth University School of Medicine, Richmond, VA, USA. ^[8] Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA. ^[9] Department of Emergency Medicine, Emory University, Atlanta, GA, USA. ^[10] Grady Memorial Hospital, Atlanta, GA, USA. ^[11] Department of Emergency Medicine, Johns Hopkins University, Baltimore, MD, USA. ^[12] Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA. ^[13] Molecular & Clinical Nutrition Section, Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Drive, Bethesda, MD, USA. ^[14] Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. ^[15] Investigational Drug Service, Vanderbilt University Medical Center, Nashville, TN, USA. ^[16] Berry Consultants, LLC, Austin, TX, USA. ^[17]

关键词 Hydrocortisone Mortality Randomized controlled trial Sepsis Septic shock Thiamine Vitamin C