Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.

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第一作者： Amna,Khamis

第一单位： Imperial College London, Department of Genomics of Common Disease, London, UK; University of Lille, CNRS, Institute Pasteur de Lille, UMR 8199 - EGID, F-59000, Lille, France.

作者： Amna,Khamis ^[1] ; Mickaël,Canouil ^[2] ; Afshan,Siddiq ^[3] ; Hutokshi,Crouch ^[3] ; Mario,Falchi ^[3] ; Manon von,Bulow ^[4] ; Florian,Ehehalt ^[5] ; Lorella,Marselli ^[6] ; Marius,Distler ^[5] ; Daniela,Richter ^[7] ; Jürgen,Weitz ^[5] ; Krister,Bokvist ^[8] ; Ioannis,Xenarios ^[9] ; Bernard,Thorens ^[10] ; Anke M,Schulte ^[4] ; Mark,Ibberson ^[9] ; Amelie,Bonnefond ^[2] ; Piero,Marchetti ^[6] ; Michele,Solimena ^[7] ; Philippe,Froguel ^[11]

作者单位： Imperial College London, Department of Genomics of Common Disease, London, UK; University of Lille, CNRS, Institute Pasteur de Lille, UMR 8199 - EGID, F-59000, Lille, France. ^[1] University of Lille, CNRS, Institute Pasteur de Lille, UMR 8199 - EGID, F-59000, Lille, France. ^[2] Imperial College London, Department of Genomics of Common Disease, London, UK. ^[3] Sanofi-Aventis Deutschland GmbH, Diabetes Research, Frankfurt, Germany. ^[4] Department of Visceral-Thoracic-Vascular Surgery, University Hospital Carl Gustav Carus and Faculty of Medicine, TU Dresden, 01307, Dresden, Germany; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital Carl Gustav Carus and Faculty of Medicine, TU Dresden, 01307, Dresden, Germany; German Center for Diabetes Research (DZD e.V.), 85764, Neuherberg, Germany. ^[5] University of Pisa, Department of Clinical and Experimental Medicine, Pisa, Italy. ^[6] Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital Carl Gustav Carus and Faculty of Medicine, TU Dresden, 01307, Dresden, Germany; German Center for Diabetes Research (DZD e.V.), 85764, Neuherberg, Germany. ^[7] Lilly Research Laboratories, Eli Lilly, 46285-0001, Indianapolis, IN, USA. ^[8] Vital-IT Group, Swiss Institute of Bioinformatics, 1015, Lausanne, Switzerland. ^[9] Center for Integrative Genomics, University of Lausanne, Genopode Building, Lausanne, 1015, Switzerland. ^[10] Imperial College London, Department of Genomics of Common Disease, London, UK; University of Lille, CNRS, Institute Pasteur de Lille, UMR 8199 - EGID, F-59000, Lille, France. Electronic address: p.froguel@imperial.ac.uk. ^[11]

关键词 Genetics Islets Laser capture microdissection Type 2 diabetes eQTLs

主题词碱性螺旋-环-螺旋亮氨酸拉链转录因子类(Basic Helix-Loop-Helix Leucine Zipper Transcription Factors);糖尿病, 2型(Diabetes Mellitus, Type 2);人类(Humans);胰岛(Islets of Langerhans);膜蛋白质类(Membrane Proteins);肽合酶类(Peptide Synthases);多态性, 单核苷酸(Polymorphism, Single Nucleotide);数量性状基因座位(Quantitative Trait Loci)

DOI 10.1016/j.molmet.2019.03.004

PMID 30956117

发布时间 2021-12-04

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Molecular metabolism

2019年24卷

98-107页

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Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.

Molecular metabolism

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Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes.

Molecular metabolism

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Molecular metabolism

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