A phase 1, randomized double-blind, placebo controlled trial to evaluate safety and efficacy of epigallocatechin-3-gallate and cognitive training in adults with Fragile X syndrome.

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第一作者： Rafael,de la Torre

第一单位： IMIM-Hospital del Mar Medical Research Institute, E-08003 Barcelona, Spain; CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), E-08003 Barcelona, Spain; University Pompeu Fabra (CEXS-UPF), E-08003 Barcelona, Spain. Electronic address: rtorre@imim.es.

作者： Rafael,de la Torre ^[1] ; Susana,de Sola ^[2] ; Magí,Farré ^[3] ; Laura,Xicota ^[2] ; Aida,Cuenca-Royo ^[2] ; Joan,Rodriguez ^[2] ; Alba,León ^[4] ; Klaus,Langohr ^[5] ; María,Gomis-González ^[6] ; Gimena,Hernandez ^[2] ; Susanna,Esteba ^[7] ; Laura,Del Hoyo ^[2] ; Júdit,Sánchez-Gutiérrez ^[8] ; Maria José,Cortés ^[9] ; Andrés,Ozaita ^[6] ; Josep María,Espadaler ^[4] ; Ramón,Novell ^[7] ; Rafael,Martínez-Leal ^[9] ; Montserrat,Milá ^[10] ; Mara,Dierssen ^[11] ; TESXF Study Group

作者单位： IMIM-Hospital del Mar Medical Research Institute, E-08003 Barcelona, Spain; CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), E-08003 Barcelona, Spain; University Pompeu Fabra (CEXS-UPF), E-08003 Barcelona, Spain. Electronic address: rtorre@imim.es. ^[1] IMIM-Hospital del Mar Medical Research Institute, E-08003 Barcelona, Spain; CIBER of Physiopathology of Obesity and Nutrition (CIBEROBN), E-08003 Barcelona, Spain. ^[2] Autonomous University of Barcelona (UDIMAS-UAB), E-08003 Barcelona, Spain. ^[3] Neurofunctionality of Brain and Language Research Group-Neurosciences Program, IMIM-Hospital del Mar Medical Research Institute, E-08003 Barcelona, Spain. ^[4] IMIM-Hospital del Mar Medical Research Institute, E-08003 Barcelona, Spain; Polytechnic University of Catalonia, E-08034 Barcelona, Spain. ^[5] University Pompeu Fabra (CEXS-UPF), E-08003 Barcelona, Spain. ^[6] Parc Hospitalari Martí í Julià-Institut d'Assistència Sanitària, E-17190 Salt, Spain. ^[7] Fundació Privada Espai Salut, Corporación Fisiogestión, E-08009 Barcelona, Spain. ^[8] Intellectual Disabilities and Developmental Disorders Research Unit (UNIVIDD), Fundació Villablanca, IISPV, URV, CIBERSAM, E-43206, Reus, Spain. ^[9] Biochemistry and Molecular Genetics Department, Hospital Clínic I Provincial de Barcelona, E-08036, Spain. ^[10] IMIM-Hospital del Mar Medical Research Institute, E-08003 Barcelona, Spain; University Pompeu Fabra (CEXS-UPF), E-08003 Barcelona, Spain; Center for Genomic Regulation (CRG), E-08003 Barcelona, Spain; CIBER of Rare Diseases (CIBERER), E-08003 Barcelona, Spain; The Barcelona Institute of Science and Technology, E-08003 Barcelona, Spain. Electronic address: mara.dierssen@crg.eu. ^[11]

关键词 Cognition Epigallocatechin gallate Fragile-X syndrome Functionality