换一批Dual-targeting and microenvironment-responsive micelles as a gene delivery system to improve the sensitivity of glioma to radiotherapy.
第一作者：
Xiuxiu,Jiao
第一单位：
Department of Pharmaceutics, Shanghai General Hospital, Shanghai Jiao Tong University of Medicine, Shanghai 200080, China.
作者：
关键词
ATCC, American Type Culture CollectionArg, arginineBBB, blood–brain barrierBBTB, blood—brain tumor barriersCMC, critical micelle concentrationCell-penetrating peptidesDTSSP, 3,3′-dithiobis(sulfosuccinimidylpropionate)DTT, dithiothreitolFBS, fetal bovine serumGBM, glioblastoma multiformeGSH, glutathioneGene deliveryGlioma-targetingKnR8, cholesterol-polylysine-polyarginine peptide, n = 3, 5, 7Lys, lysineMMP-2, matrix metalloproteinase 2MWCO, molecular weight cutoffMicroenvironment-responsive micellesPDI, polydispersity indexPE, plating efficiencyPEI, polyethylenimineRT, radiotherapyRadiosensitizerch-Kn(s-s)R8-An, the disulfide cross-linked cholesterol-polylysine-polyarginine peptide core-shell polymer micelles modified with angiopep-2, n = 3, 5, 7ch-KnR8-An, the non-cross-linked cholesterol-polylysine-polyarginine peptide core-shell polymer micelles modified with angiopep-2, n = 3, 5, 7pDNA, plasmid DNA
DOI
10.1016/j.apsb.2018.12.001
PMID
30972284
发布时间
2023-10-06
- 浏览8
Acta pharmaceutica Sinica. B
2019年9卷2期
381-396页
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