换一批Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy.
第一作者：
Lu,Zhong
第一单位：
Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
作者：
关键词
AD-B-PEG, the pH-responsive adamantane-PEG conjugateAD-O-PEG, the non-pH sensitive adamantane-PEG conjugateADA, 1-adamantane carboxylic acidAUC, area under the plasma concentration—time curveActive-targetingBenzoic imine linkageCLSM, confocal laser scanning microscopeCancer therapyDAPI, 2-(4-amidinophenyl)-6-indolecarbamidine dihydrochlorideDCC, N,N′-dicyclohexylcarbodiimideDCM, dichloromethaneDDS, drug delivery systemsDL, drug-loading contentDLS, dynamic light scatteringDMAP, 4-dimethylaminopyrideineDMEM, Dulbecco?s modified Eagle?s mediumDiR, 1,1′-dioctadecyltetramethyl indotricarbocyanine iodideDox/HCVBP, Dox-loaded hyaluronic acid-based transformable supramolecular nanoplatformDox/HCVOP, Dox-loaded hyaluronic acid-based untransformable supramolecular nanoplatformDox·HCl, doxorubicin hydrochlorideEDC, 1-ethyl-3-(3-dimethyalminopropl) carbodiimideEE, encapsulation efficiencyFBS, fetal bovine serumH&E, hematoxylin and eosinHA, hyaluronic acidHA-CD, hydroxypropyl-β-cyclodextrin grafted hyaluronic acid polymerHCBP, hydroxypropyl-β-cyclodextrin grafted hyaluronic acid polymer and pH-responsive adamantane-PEG conjugate inclusion complexHCPs, hydroxypropyl-β-cyclodextrin grafted hyaluronic acid polymer and adamantane-PEG conjugate inclusion complexesHEPES, 4-(2-hydroxyethyl)-1-piperazineethanesul-fonic acidHOBT, 1-hydroxybenzotriazoleHPCD, hydroxypropyl-β-cyclodextrinHyaluronic acidMW, molecular weightNPs, nanoparticlesNatural ligandPCC, Pearson?s correlation coefficientPDI, polydispersity indexPEG dilemmaRES, reticuloendothelial systemRPMI-1640, Roswell Park Memorial Institute-1640Supramolecular nanoplat-formTHF, tetrahydrofuranTUNEL, terminal deoxynucleotidyl transferased dUTP nick end labelingTransformative nanoparti-clesVES, vitamin E succinatepHe, the extracellular pH
DOI
10.1016/j.apsb.2018.11.006
PMID
30972285
发布时间
2023-10-06
- 浏览14
Acta pharmaceutica Sinica. B
2019年9卷2期
397-409页
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